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KMID : 0363819950290030328
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Korean Journal of Nuclear Medicine
1995 Volume.29 No. 3 p.328 ~ p.331
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99mTc Labeling and Biodistribution of PRODD as a Cerebral Blood Flow Imaging Radiopharmaceutical
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정수욱
정재민/이동수/조정혁/오승준/정준기/이명철/고창순
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Abstract
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99mTc labeled PnAO(propylene amine oxime) derivatives have been widely studied as brain perfusion agents. We synthesized and characterized a PnAO derivative, (RR/SS/meso)-4,8-diaza-3.9-dimethylundecane-2, 10-dione bisoxime(PRODD). Proton-NMR
spectroscopy and thin layer chromatography(silica gel) were performed for its characterization. PRODD was labeled with 99mTc using stannous chloride as reducing agent. The labeling efficiency was determined to be about 85%.
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KEYWORD
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